RESEARCH STUDY Controlling Gait Coordination with STN-DBS Improves Freezing of Gait in Parkinson’s disease
نویسندگان
چکیده
Background of the Study Freezing of gait (FOG), or a sudden, brief inability to generate normal stepping movements, is a common symptom of Parkinson’s disease (PD) that affects more than 50% of patients with PD. However, unlike most Parkinson’s symptoms, FOG is resistant to PD medications and the effects of subthalamic nucleus deep brain stimulation (STN-DBS; or therapy that sends electricity through electrodes (metal conductors) to specific parts of the brain that control movement) is still unknown. Since FOG is one of the leading causes of falls and reduced quality of life in patients with PD, there is a significant need to effectively control FOG episodes in PD.
منابع مشابه
STN-DBS frequency effects on freezing of gait in advanced Parkinson disease.
BACKGROUND Severe gait disturbances and freezing episodes (frequently resistant to optimal dopaminergic treatment) often appear in advanced Parkinson disease (PD). Even several years after initiation, high-frequency subthalamic nucleus deep brain stimulation (STN-DBS) is still very effective for controlling segmental symptoms. However, there are no long-term data on the management of gait disor...
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Background Subthalamic nucleus deep brain stimulation (STN-DBS) reduces tremor, muscle stiffness, and bradykinesia in people with Parkinson's Disease (PD). Walking speed, known to be reduced in PD, typically improves after surgery; however, other important aspects of gait may not improve. Furthermore, balance may worsen and falls may increase after STN-DBS. Thus, interventions to improve balanc...
متن کاملEffect of bilateral deep brain stimulation of the subthalamic nucleus on freezing of gait in Parkinson's disease.
OBJECTIVE A prospective cohort study to evaluate the efficacy of bilateral subthalamic nucleus deep brain stimulation (STN-DBS) on freezing of gait (FOG) in patients with advanced Parkinson's disease. METHODS Patients (n = 10) with advanced Parkinson's disease were surgically implanted with microelectrodes to facilitate STN-DBS. Evaluations of FOG, motor function, activities of daily living ...
متن کاملDeep Brain Stimulation of the Subthalamic and Pedunculopontine Nucleus in a Patient with Parkinson's Disease
Deep brain stimulation (DBS) of the pedunculopontine nucleus (PPN) is a novel therapy developed to treat Parkinson's disease. We report a patient who underwent bilateral DBS of the PPN and subthalamic nucleus (STN). He suffered from freezing of gait (FOG), bradykinesia, rigidity and mild tremors. The patient underwent bilateral DBS of the PPN and STN. We compared the benefits of PPN-DBS and STN...
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Background It has been suggested that parkinsonian [Parkinson's disease (PD)] patients might have a "dominant" (DOM) subthalamic nucleus (STN), whose unilateral electrical stimulation [deep brain stimulation (DBS)] could lead to an improvement in PD symptoms similar to bilateral STN-DBS. Objectives Since disability in PD patients is often related to gait problems, in this study, we wanted to ...
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